英国牛津大学博士后职位—神经退行性疾病的新型治疗药物发现

英国牛津大学博士后职位—神经退行性疾病的新型治疗药物发现

牛津大学（University of Oxford），简称“牛津”（Oxford），位于英国牛津，是一所公立研究型大学，采用传统学院制。是罗素大学集团成员，被誉为“金三角名校”、“G5超级精英大学”，全球大学校长论坛成员。牛津大学的具体建校时间已不可考，但有档案明确记载的最早的授课时间为1096年，亨利二世在1167年禁止英国学生就读巴黎大学，因得到了英国王室的大力支持而快速发展。

Postdoctoral Research Assistant

University of Oxford

United Kingdom

January 08, 2024

Contact:N/A

Offerd Salary:£36,024 - £44,263

Location:N/A

Working address:N/A

Contract Type:fixed term contract

Working Time:Full time

Working type:N/A

Ref info:N/A

Postdoctoral Research Assistant

Centre for Medicines Discovery, NDM Research Building, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7FZ

We are seeking to appoint a Postdoctoral Research Assistant with expertise in endo-lysosomal biology and iPSC-derived neuronal cultures to join the Alzheimer's Research UK Oxford Drug Discovery Institute (ARUK-ODDI) at Centre for Medicines Discovery, Nuffield Department of Medicine.

You will become an integral part of the Organelle Biology team within the ODDI and report to the team leader (Dr Margarida Ruas). As an experienced molecular and cell biologist with a background in neurodegeneration, you will be responsible for designing and executing experimental plans to support the validation of targets, and the discovery of novel therapeutic agents. You will be expert in several cutting-edge methodologies (iPSC-derived neuronal cells, high content imaging, ratiometric fluorescent reporters) and be able to provide scientific and technical advice to students and colleagues within the ARUK-ODDI, or collaborating academic groups. You will provide the experimental and analytical expertise required to prosecute target validation and drug discovery for mechanisms regulating subcellular trafficking and organelle homeostasis in the context of Alzheimer's and Parkinson's disease.

It is essential that you hold a PhD/DPhil (or close to completion) in Cell Biology or related subject, together with significant research experience relevant to the field of endo-lysosomes and subcellular trafficking. You will also have experience in cell culture, including human iPSC-derived neuronal lines, and manipulation of cell lines by lentiviral transduction and transfection for manipulation of gene expression (e.g. siRNA, CRISPRi/a, overexpression). You will have excellent attention to detail and ability to work as part of a team and of productive collaborative research, with excellent communication skills.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 October 2025, with possibility of extension and is funded by the Alzheimer's Research UK.

Only applications received before 12 midday on 8 January 2024 will be considered. Please quote 168235 on all correspondence.

Contact Person : Kristina Limbu Vacancy ID : 168235 Contact Phone : 01865617971 Closing Date & Time : 08-Jan-2024 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : recruitment@ndm.ox.ac.uk Salary (£) : Grade 7: Salary in range £36,024 - £44,263 per annum

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