英国格拉斯哥大学博士后职位—MRC资助项目“评估 IL-17A 作为抑郁症状中外周-中枢串扰协调者的作用”

英国格拉斯哥大学博士后职位—MRC资助项目“评估 IL-17A 作为抑郁症状中外周-中枢串扰协调者的作用”

格拉斯哥大学（英文名：University of Glasgow）位于英国格拉斯哥市，是一所公立大学。格拉斯哥大学被称为“世界百强大学”，是罗素大学集团、Universitas 21和欧洲研究型大学协会成员。

Research Associate

University of Glassgow

Research Associate

Job purpose

To make a leading contribution to an MRC-funded project “Evaluating the role of IL-17A as an orchestrator of peripheral-central cross talk in depressive symptoms”, working with a team of cognitive neuroscientists, clinicians/mental health professionals, immunologists and statisticians.

This project seeks a clinically actionable understanding of the mechanisms that underlie depression in the context of immune mediated inflammatory diseases (IMID), delivered by state-of-the-art brain imaging. Approximately 30-40% of patients with IMID experience psychiatric comorbidity, such as depressive symptoms, often associated with proinflammatory cytokines, such as IL-17A. In this work we aim to recruit chronic IMID patients to carry out brain imaging before and after anti IL-17A treatment to study how the relevant neural pathways are affected. We plan to study these pathways in the context of reinforcement learning and decision making as these processes are often affected in depression.

This post will be responsible for simultaneous EEG-fMRI in 7T, to offer a high spatiotemporal characterisation of the relevant cortical/subcortical pathways and the mechanistic properties underlying these pathways. The post holder will have the opportunity to be involved in cutting-edge bespoke neuroimaging technology 7TfMRI-EEG and advanced data analytics to uncover and predict patterns in large multimodal datasets.

The successful candidate will also be expected to work closely with other postdoctoral fellows employed on the same project to contribute to the formulation and submission of research publications and research proposals as well as help the PIs manage the project as opportunities allow.

Main Duties and Responsibilities

1. Take a leading role in the planning and conduct of assigned research individually or jointly with the PI in accordance with the project deliverables.

2. Survey the research literature, understand the research challenges associated with the project and subject area, and develop/implement a suitable research strategy.

3. Undertake collection and analyses of simultaneous 7TfMRI-EEG data in a clinical population (e.g. psoriasis patients) and apply existing and to be developed advanced multivariate data analyses tools.

4. Document research output including analysis and interpretation of all data, maintaining records and databases, drafting technical/progress reports and papers as appropriate.

5. Contribute to the organisation, supervision, mentoring and training of postgraduate students and less experienced members of the project team to ensure their effective development.

6. Establish and sustain a track record of publications of international quality in high profile/quality refereed journals, enhancing the research impact in terms of economic/societal benefit, and gathering indicators of esteem.

7. Presentation of work at international and national conferences, at internal and external seminars, colloquia and workshops to develop and enhance our research profile.

8. Take a leading role in the identification of potential funding sources and to assist in the development of proposals to secure funding from internal and external bodies to support future research.

9. Take a leading role in developing and maintaining collaborations with colleagues across the research group/School/College/University and wider community e.g. Academic and Industrial Partners.

10. Take a leading role in team/group meetings/seminars/workshops and School research group activities to enhance the wider knowledge, outputs and culture of the School/College.

11. Contribute to the enhancement of the University's international profile in line with the University's Strategic Plan, Inspiring People Changing The World.

These key tasks are not intended to be exhaustive but simply highlight a number of major tasks which the staff member may reasonably be expected to perform.

Qualifications/Knowledge

Essential:

A1. Normally Scottish Credit and Qualification Framework level 12 PhD or alternatively possess the equivalent in professional qualifications and experience, with experience of personal development in a similar or related roles

A2. Demonstrable interest and experience in cognitive neuroscience

A3. Experience in human neuroimaging

Desirable:

B1. Demonstrable interest and experience in clinical research

B2. Prior experience in the area of human decision making and learning

Essential:

C1. Excellent programming skills in Matlab and/or R

C2. Experience with Frequentist and Bayesian robust statistics

C3. Working knowledge of FSL and/or SPM packages

C4. Demonstrable ability to work independently as well as in teams

C5. Excellent communication skills oral and written, including public presentations

Desirable:

D1. Working knowledge of Fieldtrip and/or EEGlab toolboxes

D2. Experience with computational modelling of behaviour (e.g. reinforcement learning).

Essential:

E1. Extensive experience with fMRI

E2. Proven ability to deliver quality outputs in a timely and efficient manner

E3. A track record of presentation and publication of research results in quality journals/conferences

Desirable:

F1. Experience with EEG

F2. Experience with simultaneous EEG-fMRI

F3. Experience with 7T fMRI

Terms and Conditions

Salary will be Grade 7 £39,347 - £44,263 per annum

This post is full time, and has funding for up to 24 months

As part of Team UofG you will be a member of a world changing, inclusive community, which values ambition, excellence, integrity and curiosity.

The University of Glasgow has a responsibility to ensure that all employees are eligible to live and work in the UK. If you require a Skilled Worker visa to work in the UK, you will be required to meet the eligibility requirements of the visa route to be assigned a Certificate of Sponsorship.

Please note that this post may be eligible to be sponsored under the Skilled Worker visa route if tradeable points can be used under the Skilled Worker visa rules. For more information please visit: https: // www. gov.uk/skilled- worker-visa.

As a valued member of our team, you can expect:

1 A warm welcoming and engaging organisational culture, where your talents are developed and nurtured, and success is celebrated and shared.

2 An excellent employment package with generous terms and conditions including 41 days of leave for full time staff, pension - pensions handbook https: // www. gla.ac.uk/myglasgow/payandpensions/pensions/, benefits and discount packages.

3 A flexible approach to working.

4 A commitment to support your health and wellbeing, including a free 6-month UofG Sport membership for all new staff joining the University https: // www. gla.ac.uk/myglasgow/staff/healthwellbeing/.

We believe that we can only reach our full potential through the talents of all. Equality, diversity and inclusion are at the heart of our values. Applications are particularly welcome from across our communities and in particular people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented within the University. Read more on how the University promotes and embeds all aspects of equality and diversity within our community https: // www. gla.ac.uk/myglasgow/humanresources/equalitydiversity/.

We endorse the principles of Athena Swan https: // www. gla.ac.uk/myglasgow/humanresources/equalitydiversity/athenaswan/ and hold bronze, silver and gold awards across the University.

We are investing in our organisation, and we will invest in you too. Please visit our website https: // www. gla.ac.uk/explore/jobs/ for more information.

Vacancy Ref : 152410 Close Date : 29-Aug-2024 23:45

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