英国伦敦大学学院博士后—脑血管生物学与脑癌生物学

英国伦敦大学学院博士后—脑血管生物学与脑癌生物学

伦敦大学学院（University College London，简称：UCL），位于英国伦敦，是一所公立研究型大学，也是第一所在伦敦成立的大学。学校是罗素大学集团和欧洲研究型大学联盟的成员，被誉为金三角名校之一。

Research Fellow in Brain Vascular Biology Brain Cancer Biology

Employer

University College London (UCL)

Location

England, London

Salary

£43124 - £51610 per annum + Inclusive of London Allowance

Closing date

6 Nov 2024

The Group of CNS Angiogenesis and Neurovascular Link / Brain Vasculature and Perivascular Niche headed by neurosurgeon-neuroscientist Associate Professor Dr Thomas Wälchli is one of the laboratories of the University College London (UCL) Cancer Institute in the Department of Oncology of the University College London (UCL).

Brain Vascular Biology and Brain Cancer Biology | UCL Cancer Institute - UCL - University College London

The overarching vision of the research of Associate Professor Dr Thomas Wälchli, MD-PhD, FMH neurosurgery is to understand how the brain vasculature is regulated during brain development, in the adult healthy brain, and in various vascular-dependent brain diseases such as brain tumours and brain vascular malformations. The UCL Cancer Institute is a £40 million investment in central London based at University College London (UCL), one of the world's top universities and a founding member of the Francis Crick Institute. The Institute draws together over 400 scientists working together to develop world-class basic and translational cancer research.

About the role

The Group of Brain Vasculature and Perivascular Niche focuses on vascular growth and the development of blood vessels (angiogenesis) in the brain, including endothelial cells and perivascular cells of the neurovascular unit/perivascular niche, and on brain vascular heterogeneity in development, health and disease: The main aims are: i) to understand the cellular and molecular underpinnings that govern the growth of the developing, adult, and diseased human brain vasculature at single-cell resolution, ii) to uncover the single-cell transcriptomic, genomic and epigenomic landscapes and spatial biology of the developing, adult and diseased human brain vasculature, iii) to elucidate how developmental programs regulate vascular growth/angiogenesis in the human brain tumour vasculature (patho-fetal axis / onco-fetal axis), iv) to unravel the onco-fetal programs of vascular growth/angiogenesis and immunosuppression/immunomodulation, and v) to translate these fundamental insights about the onco-fetal axis in the human brain (tumour) vasculature into clinical settings with the ultimate goal to identify novel therapeutic strategies for human brain tumours (and for other vascular-dependent diseases such as human brain vascular malformations).

The post is funded for until 31st October 2025 in the first instance, with possibility of extension.

Interviews are expected to take place on Monday the 11th of November 2024.

About you

The successful candidate is be expected to be a driving force of these highly novel, original and competitive projects, to produce independent and original research in this area, to develop and apply new concepts and to have a creative approach to problem solving.

Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

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