比利时安特卫普大学博士后—用于基础和转化痴呆研究的神经免疫类器官平台

比利时安特卫普大学博士后—用于基础和转化痴呆研究的神经免疫类器官平台

安特卫普大学（University of Antwerp），作为研究型大学，是乌德勒支网络（Utrecht Network）成员。

Postdoc Scientist Neuroimmune Organoid Platform for Fundamental and Translational Dementia Research

VIB

Antwerp, Belgium

Project description

The envisaged project presents a methodological challenge to establish neuroimmune organoid models for application in the context of various neurodegenerative diseases.

Over the last decade, organoids emerged as an attractive middle ground between 2D cell cultures, which do not fully recapitulate the 3D environment and animal models, which pose technical and ethical limits. In particular, cerebral organoids are emerging as the next step in patient-derived in vitro models for both neurodevelopmental as well as neurodegenerative diseases. However, cerebral organoids have mostly been based on neuronal cells alone, while evidence increases that the role of non-neuronal types (microglia, astrocytes, endothelial cells) is critical in these conditions. Integration of these cell types will more closely mimic the in vivo cellular environment in health and disease and constitutes the major challenge of this project. The established neuroimmune organoid technology will find a wide range of applications as models for studying fundamental mechanisms underlying cellular biology and genetic pathophysiology as well as for efficient drug screening. The recruited postdoc would lead on this challenge and would be offered an opportunity to shape the application scope of the developed technology to advance the science of all research groups at the Center.

Profile

We are looking for a talented and highly motivated junior or senior postdoctoral researcher with a strong interest in high-impact technology development and application in fundamental and translational research in neurodegenerative disease field.

You hold a PhD in genetics, immunology, neuroscience or related disciplines (or you will have obtained it by the time you start work).

Extensive expertise in working with (multicellular) organoid cultures.

Experience with single-cell data analysis is a plus.

Scientific integrity and excellence, illustrated by a strong publication track record.

Excellent communication and writing skills in English.

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