法国国家科学研究中心（CNRS）博士后—微生物学/细菌学

法国国家科学研究中心（CNRS）博士后—微生物学/细菌学

Postdoctoral Position In Microbiology/Bacteriology, H/F

Universities And Institutes Of France

Organisation/Company: CNRS

Research Field: Biological sciences › Biology

Researcher Profile: Recognised Researcher (R2)

Application Deadline: 22/07/2022 23:59 - Europe/Brussels

Location: France › GIF SUR YVETTE

Type Of Contract: Temporary

Job Status: Full-time

Hours Per Week: 35

Offer Starting Date: 01/10/2022

Eu Research Framework Programme: H2020 / Marie Skłodowska-Curie Actions

The host laboratory, lead by Nicolas Mirouze (ORCID: 0000-0002-1038-0495) has an extensive experience in the investigation of natural competence for genetic transfoormation in several model organisms. The main originality of this project resides in our choice to study a new model organism. Indeed, taking advantage of the knowledge accumulated in 'old' model organisms and of an important set of preliminary data, we propose to investigate Horizontal Gene Transfer (HGT) through competence and genetic transformation in S. aureus, an important human pathogen often associated to multi-antibiotic resistances. Identifying the signal leading to competence development, characterizing the regulation pathways transmitting this signal as well as deciphering the actors responsible for DNA binding and transport during transformation should allow us to understand how this bacterium evolved to become a major human pathogen. In order to investigate all these aspects we propose to conduct high- throughput and unbiased approaches (Transposon-sequencing, Yeast-Two-Hybrid) as well as to verify hypotheses formulated thanks to our preliminary data (through genetics, RNA-sequencing, microsocpy...). Finally, we propose to verify the results obtained in vivo. To do so, a S. aureus strain collection as well as infectious modeles (mice) will be available through our collaborators.

The postdoctoral researcher will be involved in one of the host laboratory research project which aims to investigate the development of natural competence (an environmental adaptation leading to horizontal gene transfer through genetic transformation) in the human pathogen Staphylococcus aureus. The candidate, helped by the host laboratory will apply to the European Commission Marie Sklodowska-Curie Postdoctoral Fellowship (HORIZON- MSCA-2022-PF-01).

The host laboratory is part of the Microbiology department within the Institute for Integrative Biology of the Cell (I2BC, https: // www. i2bc.paris- saclay.fr/). The host institute (CNRS/CEA/UNiversité Paris-Saclay) is divided in 5 scientific departments (700 researchers), linked to numerous technological platforms (microscopy, high throughput sequencing, biochemistry...).

Eligibility criteria

-Experience in microbiology and molecular biology -Knowledge and experience with Stahylococcus aureus -Ability to work collaboratively -Good autonomy and strong organizational skills -Strong motivation to work

Additional comments

Applicants will be asked to provide a CV including a list of publications, a cover letter describing their research interests and motivations, and the names and contact information of two references.

Web site for additional job details

https: // emploi.cnrs.fr/Offres/CDD/UMR9198-NICMIR-002/Default.aspx

Required Research Experiences

RESEARCH FIELD

Biological sciences › Biology

YEARS OF RESEARCH EXPERIENCE

1 - 4

Offer Requirements

REQUIRED EDUCATION LEVEL

Biological sciences: PhD or equivalent

REQUIRED LANGUAGES

FRENCH: Basic

Contact Information

Organisation/Company: CNRS

Department: Institut de BiologieIntégrative de la Cellule

Organisation Type: Public Research Institution

Website: https:// www. i2bc.paris-saclay.fr

Country: France

City: GIF SUR YVETTE