美国加州大学旧金山分校博士后职位

　　招聘简介：

　　博士后访问学者

　　马克·莫阿瑟

　　旧金山，CA，美国

　　博士后职位现在在加州大学旧金山分校海伦·迪勒家庭综合癌症中心的Mission Bay校区为一位对癌症生物学或转化癌症研究感兴趣的杰出候选人提供。我们的实验室对上皮癌中的酪氨酸激酶癌基因感兴趣，重点研究了酪氨酸激酶癌基因的HER和SRC家族。目前，一个职位是开放的研究SRC信号，虽然雄心勃勃的候选人可能会在我们的研究项目中追求更广泛的工作范围。

　　尽管有大量关于SRC激酶转化潜能的证据，但它们在人类癌症中的作用尚未证实，对SRC抑制剂的反应也不明显。这使得我们重新研究SRC激酶在正常生理学和癌症发病机制中的作用。我们实验室开发的新证据表明，SRC激酶的功能比以前想象的更复杂，它们在人类癌症中的参与可能与其他激酶致癌基因不同。这项工作建立在我们实验室已经建立的大量数据和模型系统和试剂的基础上。

　　英文原文：

　　Postdoctoral Scholar

　　Mark Moasser

　　San Francisco, CA, United States

　　Postdoctoral position is available now at the UCSF Helen Diller Family Comprehensive Cancer Center at the mission bay campus for an outstanding candidate interested in cancer biology or translational cancer research. Our laboratory is interested in tyrosine kinase oncogenes in epithelial cancers, with a focus on the HER and Src family of tyrosine kinase oncogenes. A position is currently open to study Src signaling, although ambitious candidates may pursue a broader scope of work within our research program.

　　Despite an abundance of evidence regarding the transforming potential of Src kinases, their role in human cancers remains unproven and response to Src inhibitors unimpressive. This has led us to re-examine how Src kinases function in normal physiology and in cancer pathogenesis. New evidence, developed in our lab, has revealed that Src kinases have functions more complex than previously thought, and their engagement in human cancer may not follow the same paradigms as other kinase oncogenes. This work builds on a substantial body of data and model systems and reagents already established in our lab.

　　Our work encompasses a wide range of in vitro and in vivo experimental techniques including protein biochemistry and signaling, gene expression, gene knockdown and knockout models, mouse xenograft and genetic models, and interrogation of clinical samples. We are also involved in several drug discovery efforts to test novel interventional strategies. UCSF is a highly collaborative environment and our laboratory is involved in collaborations with multiple other research programs within the scientific community including programs in systems biology, small molecule discovery, chemistry and chemical biology, and structural biology. More information available at www.lab.moasser.com. Highly motivated candidates with an MD or PhD and a strong background in molecular and cellular biology please send CV to Mark M. Moasser, MD at mark.moasser@ucsf.edu