德国慕尼黑工业大学博士后职位—微生物组研究

德国慕尼黑工业大学博士后职位—微生物组研究

Postdoctoral Researcher (m/f/d) in Microbiome Research

Technische Universität München

Description

The Schirmer lab is part of the ZIEL - Institute for Food & Health at the Technical University of Munich and located in Freising-Weihenstephan. The research of our lab focuses on the human microbiome, especially gut microbes,

and investigates potential mechanisms of host-microbial interactions in health and disease. We are particular interested in the role of the microbiome in inflammatory and auto-immune diseases and how hormone-microbiome interactions impact female health.

To address these questions, we use integrated multi-omics analyses (metagenomics, metatranscriptomics and metabolomics) to identify diseaseassociated bacterial strains and their metabolites. These strains are subsequently isolated and cultured in the lab.

Candidate profile

We are looking for an outstanding highly-motivated postdoctoral researcher with the ambition and commitment to achieve excellence in a highly productive environment. The activities surrounding this position will be focused on experimental work

for the validation of predicted host-microbial interactions based on human cohort data and represent an exciting opportunity to discover the underlying mechanisms of the microbiome in human diseases.

Bacterial strains and predicted host-microbial interactions will be prioritized based on computational analyses of multi-omics data from large population studies. The candidate for this project will be responsible for DNA/RNA extractions from human samples

and the isolation, cultivation and characterization of bacterial strains from  these samples (including stool, saliva and vaginal swabs).

Tasks

• Sample handling (e.g., DNA/RNA extractions)

• Isolation and cultivation of disease-related bacterial strains

• Functional characterization of bacterial strains (gene expression and metabolic capabilities)

• Characterizing the immunomodulatory potential of bacteria (including human cell assays) and investigating hormone-microbe interactions

• Lead and contribute to the generation of publications, grant applications, and protocols

• Network with our national and international collaborators and present our work at conferences and scientific meetings

Requirements

• PhD in microbiology or a relevant field

• Experience in classical and molecular microbiology techniques

• Experience with culturing bacteria (in particular anaerobes) and isolating  bacterial strains from human samples

• Additional qualifications:

o Experience with immunological assays and human cell lines is an advantage

o Experience/interest in human organoids is an advantage

• Experience or strong interest in human microbiome research

• Strong publication record, excellent communication skills, and high proficiency in English (presentation and writing skills)

• Self-motivated and enthusiastic to work in an interactive, international research environment, ability to work independently and as part of a team

• Excellent organization and time management skills required