英国剑桥大学MRC剑桥干细胞研究所博士后职位

英国剑桥大学MRC剑桥干细胞研究所博士后职位

Post-doctoral Research Associate (Lee Lab) (Fixed Term)

University of Cambridge

Description

The lab of Dr Joo-Hyeon Lee (https: // www. stemcells.cam.ac.uk/people/pi/lee) at the Wellcome - Medical Research Council Cambridge Stem Cell Institute is looking for a Postdoctoral Fellow/Research Associate to work on an innovative, multi-disciplinary, and collaborative project that investigates "the mechanisms that lead to cellular reprogramming and lineage plasticity in lung regeneration and disease state."

The successful candidates will benefit from multi-disciplinary collaborations, exciting preliminary findings, and highly innovative experimental model systems (e.g. in vivo novel mosaic genetic mouse models, ex vivo mouse and patient-derived human lung organoids, single cell multi-omics, high-resolution imaging platforms, biophysical clonal modelling, etc.) enabling functional interrogation of cell fates and states during regeneration and disease initiation (Lee Lab Publications: Lee et al. Cell 2017; Ombrato et al. Nature 2019; Choi et al. Cell Stem Cell 2020; Youk et al. Cell Stem Cell 2020; Yum et al. Nature 2021; Choi et al. Nature Cell Biol. 2021; Jeon et al. EMBO J. 2022).

Candidates should be enthusiastic about collaborative and interdisciplinary research, the use of innovative technologies, productive, and highly motivated to develop as independent scientists. A strong background in development and stem cell biology, as well as expertise in animal models (preferably genetic mouse models), are required for this post. A background in epigenetics and metabolism is desirable. Experience in primary cell cultures, flow cytometry, CRISPR genome editing, and computational analysis would be advantageous. Candidates will work closely with lab members and collaborators to ensure the quality of our work.

The Wellcome - Medical Research Council Cambridge Stem Cell Institute is an international centre of excellence for stem cell research and regenerative medicine. Scientists in the Institute collaborate to advance our knowledge of various stem cell types and to perform pioneering work in translational research areas, providing the foundation for new medical treatments (https: // www. stemcells.cam.ac.uk/). Appointment at Research Associate level is dependent on having a PhD, an equivalent research doctorate. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once PhD has been awarded.

Informal enquiries should be addressed to Dr Joo-Hyeon Lee at jhl62@cam.ac.uk.

Fixed-term: The funds for this post are available for 24 months in the first instance.