英国剑桥大学博士后职位---神经科学/α-突触核蛋白

英国剑桥大学博士后职位---神经科学/α-突触核蛋白

剑桥大学（University of Cambridge；勋衔：Cantab），坐落于英国剑桥郡，是一所公立研究型大学，采用传统学院制。学校是罗素大学集团成员，全球大学校长论坛成员，被誉为“金三角名校”和“G5”之一。 剑桥大学是英语世界中第二古老的大学，前身是一个于1209年成立的学者协会。 [

Research Associate (Neuroscience/alpha-synuclein/iPSC/CRISPR)

University of Cambridge

Applications are invited for a post-doctoral position in the group of Dr Janin Lautenschläger at the Cambridge Institute for Medical Research (CIMR, Biomedical Campus, University of Cambridge). Our lab studies the function of alpha-synuclein, a synaptic protein involved in Parkinson's disease. We have shown that alpha-synuclein undergoes protein phase separation and are now aiming to understand how alpha-synuclein phase separation is regulated and which functional role this plays in synaptic transmission.

The successful candidate would have a strong interest in molecular mechanisms of neurodegeneration and experience with iPSC-derived neuronal cultures including viral transgene expression and CRISPR/Cas9 gene editing. In addition, experience in molecular biology (i.e. molecular cloning, Western blot) and in microscopy are essential. Experience in advanced imaging i.e. FRAP, ratiometric dyes like Synapto-pHluorin, Airyscan, SIM and/or FLIM would be beneficial. We will be starting to work with alpha-synuclein triplication, knock-out and isogenic control iPSC-derived neurons and aim to develop further models to study the functional output of decreased/increased alpha-synuclein phase separation.

A PhD in Molecular Neuroscience (or soon to be awarded) or similar areas is essential. The candidate will be able to independently manage time and  experiments to generate data for publication, as supported by a track record of peer-reviewed papers. The candidate will be able to troubleshoot experiments and develop novel research approaches/ideas.

Please submit your C.V. and a cover letter describing how you match the criteria for the post and why you are applying for this role.

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