英国普利茅斯大学博士后—研究细胞外基质粘附与细胞周期进程之间的联系

英国普利茅斯大学博士后—研究细胞外基质粘附与细胞周期进程之间的联系

普利茅斯大学（University of Plymouth）始建于1862年，是一所坐落于英格兰普利茅斯的公立综合性研究型大学，为海洋可再生能源研究联盟、江苏—英国高水平大学联盟、英国大学联盟、英联邦大学协会、欧洲大学协会成员。

Post-Doctoral Research Fellow

University of Plymouth

Post-Doctoral Research Fellow

Description

Post-Doctoral Research Fellow position to study links between extracellular matrix adhesion and cell-cycle progression

Based in the Faculty of Health, the Peninsula Medical School is committed to three core aims: outstanding clinical education; strong social engagement; and world-class research which all feature strongly in the student learning experience. A key strength is a close relationship with NHS partners, with early clinical contact for all students. The South West offers healthcare and learning opportunities of exceptional quality; Derriford is one of Europe's largest hospitals and the only trauma centre in Devon and Cornwall. A further strength is our scholarly approach to education, supported by the Division of Education Scholarship. The Plymouth Institute of Health and Care Research is the core of research activity, providing a thriving community that conducts adventurous world-leading research with the explicit purpose of improving the health and care of the populations we serve.

Proliferation of cells is a tightly regulated process, with most cells in tissues existing in a reversible non-proliferative quiescent state. Quiescence is a maintained state, but the mechanisms that promote cell quiescence remain poorly understood. Disruption of the balance between quiescence and proliferation leads to loss of tissue function and contributes to diseases including cancer, atherosclerosis, and fibrosis. The extracellular matrix (ECM), the network of proteins that supports and surrounds cells in tissues, is emerging as a regulator of the balance between cell proliferation and quiescence. However, the signalling pathways downstream of adhesion to ECM proteins that promote proliferation or quiescence have not been defined. Understanding how ECM proteins can influence cell quiescence and proliferation will therefore increase our understanding of physiological processes at a fundamental level and identify mechanisms by which normal physiology is disrupted in disease.

We are seeking a Post-Doctoral Research Fellow to join the lab in Plymouth for 12 months to undertake a specific research project defining the mechanisms by which ECM adhesion influences cell quiescence and proliferation. This will incorporate the use of a range of techniques including: confocal microscopy, mass-spectrometry-based proteomics, flow cytometry, biochemical approaches, and RNAseq.

Main Duties and Responsibilities:

Manage and develop the research project, with assistance from mentor

Generate, analyse and interpret data

Contribute to writing grant applications

Disseminate findings via publication, seminars and attending conferences

Supervise and provide guidance to students

Skills and Attributes

PhD (or near completion) in a relevant research area

Experience in mammalian cell culture is essential. Lab skills in ECM adhesion, flow cytometry, microscopy, Western blotting, and sample preparation for proteomic and genomic analysis are desirable.

Ability to communicate complex ideas clearly.

Ability to work independently, but as part of a team working towards a common goal.

Excellent record keeping and data management skills coupled with a high level of analytical ability.

Please demonstrate how you meet the essential criteria outlined in the knowledge, qualifications, training and experience elements of the job description in your supporting statement.

For an informal discussion to find out more about the role then please contact Matthew Jones: by email at matt.jones-32@plymouth.ac.uk

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